杨宁介入医学网

 

1. 载药微球-顺铂

ioxaglic and iohexol contrast the elution profile was similar with cisplatin fractions of  15%,40%,70% and 95% at 1,3,6 and 24 hours

respectively

• Conducted a preclinical study in vitro

• In vivo in patients with CRC measuring oxaliplatin concentration in target lesion (by biopsy) and plasma

• Highest of drug tested was 400mg oxaliplatin/50mg HepaSphere

• Working dose : 50mg oxaliplatin + 1 vial of Hepa 50-100 for 15min

2. Gupta et al. “Hepatic Arterial Embolization with Doxorubicin-Loaded Superabsorbent Polymer Microspheres in a Rabbit Liver Tumor Model.” Cardiovasc Intervent Radiol 2011; 34(5):1021-30.

3. Lee KH, Liapi E, Vossen JA, Buijs M, Ventura VP, Georgiades C, Hong K, Kamel I, Torbenson MS, Geschwind JF. Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy. J Vasc Interv Radiol. 2008 Oct;19(10):1490-6. doi: 10.1016/j.jvir.2008.06.008. Epub 2008 Aug 27.

4. Namur J, Wassef M, Millot JM, Lewis AL, Manfait M, Laurent A. Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model. J Vasc Interv Radiol. 2010 Feb;21(2):259-67. doi: 10.1016/j.jvir.2009.10.026.

5. Mori W, Masuda M, Miyanaga T. Hepatic artery ligation and tumor necrosis in the liver. Surgery. 1966;59:359–363.

6. . Doyon D, Mouzon A, Jourde AM, Regensberg C, Frileux C. [Hepatic, arterial embolization in patients with malignant liver tumours (author’s transl)] Ann Radiol (Paris) 1974;17:593–603.

7. Yamada R, Sato M, Kawabata M, Nakatsuka H, Nakamura K, Takashima S. Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology. 1983;148:397–401.

8. Lee KH1, Liapi EA, Cornell C, Reb P, Buijs M, Vossen JA, Ventura VP, Geschwind JF. Doxorubicin-loaded QuadraSphere microspheres: plasma pharmacokinetics and intratumoral drug concentration in an animal model of liver cancer（免费全文）. Cardiovasc Intervent Radiol. 2010 Jun;33(3):576-82. 

9. van Malenstein H, Maleux G, Vandecaveye V, Heye S, Laleman W, van Pelt J, Vaninbroukx J, Nevens F, Verslype C. A randomized phase II study of drug-eluting beads versus transarterial chemoembolization for unresectable hepatocellular carcinoma（免费全文）. Onkologie. 2011;34(7):368-76. doi: 10.1159/000329602. Epub 2011 Jun 21.

10, Malagari K, Pomoni M, Kelekis A, Pomoni A, Dourakis S, Spyridopoulos T, Moschouris H, Emmanouil E, Rizos S, Kelekis D. Prospective randomized comparison of chemoembolization with doxorubicin-eluting beads and bland embolization with BeadBlock for hepatocellular carcinoma. Cardiovasc Intervent Radiol. 2010 Jun;33(3):541-51. doi: 10.1007/s00270-009-9750-0. Epub 2009 Nov 24.

11. Grosso M, Vignali C, Quaretti P, Nicolini A, Melchiorre F, Gallarato G, Bargellini I, Petruzzi P, Massa Saluzzo C, Crespi S, Sarti I. Transarterial chemoembolization for hepatocellular carcinoma with drug-eluting microspheres: preliminary results from an Italian multicentre study. Cardiovasc Intervent Radiol. 2008 Nov-Dec;31(6):1141-9. doi: 10.1007/s00270-008-9409-2. Epub 2008 Aug 12.

12. Kos S, Wasan E, Weir G, Reb P, Cornell C, Ford JA, Liu DM.  Elution characteristics of doxorubicin-loaded microspheres differ by drug-loading method and microsphere size. J Vasc Interv Radiol. 2011 Mar;22(3):361-8. doi: 10.1016/j.jvir.2010.11.032.

13. Liu DM, Kos S, Buczkowski A, Kee S, Munk PL, Klass D, Wasan E. Optimization of doxorubicin loading for superabsorbent polymer microspheres: in vitro analysis.  Cardiovasc Intervent Radiol. 2012 Apr;35(2):391-8. doi: 10.1007/s00270-011-0168-0. Epub 2011 May 13.

14. Dekervel J, van Malenstein H, Vandecaveye V, Nevens F, van Pelt J, Heye S, Laleman W, Van Steenbergen W, Vaninbroukx J, Verslype C, Maleux G. Transcatheter arterial chemoembolization with doxorubicin-eluting superabsorbent polymer microspheres in the treatment of hepatocellular carcinoma: midterm follow-up. J Vasc Interv Radiol. 2014 Feb;25(2):248-55.e1. doi: 10.1016/j.jvir.2013.10.017. Epub 2013 Dec 2.

15. Seki A1, Hori S.Switching the loaded agent from epirubicin to cisplatin: salvage transcatheter arterial chemoembolization with drug-eluting microspheres for unresectable hepatocellular carcinoma. Cardiovasc Intervent Radiol. 2012 Jun;35(3):555-62. doi: 10.1007/s00270-011-0176-0. Epub 2011 May 12.

16. Johannes Lammer, corresponding author, Katarina Malagari,  Thomas Vogl, Frank Pilleul, Alban Denys, Anthony Watkinson, Michael Pitton, Geraldine Sergent, Thomas Pfammatter, Sylvain Terraz, Yves Benhamou, Yves Avajon, Thomas Gruenberger, Maria Pomoni, Herbert Langenberger, Marcus Schuchmann, Jerome Dumortier, Christian Mueller, Patrick Chevallier, Riccardo Lencioni, and On Behalf of the PRECISION V Investigators.  Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study Cardiovasc Intervent Radiol. 2010 Feb; 33(1): 41–52.