杨宁介入医学网

简介 Hepatic artery infusion chemotherapy (HAIC) is a treatment modality for advanced hepatocellular carcinoma (HCC). 肝动脉输注化疗(HAIC)是治疗晚期肝癌(HCC)的一种治疗方式。 HAIC entails infusing chemotherapeutic agents directly into hepat...

The following characteristics of HAIC render it a suitable candidate for combination with other antineoplastic agents for advanced HCC: it is associated with fewer systemic adverse events compared with intravenous chemotherapy, and its cyt...

Lack of Industry Incentive for Conducting Trials 开展试验缺乏行业激励 The patents for the main chemotherapeutic agents used in HAIC, including cisplatin, oxaliplatin, 5-FU, and epirubicin, have expired, thus weakening the motivation for th...

Insufficient Technical Standardization Techniques and protocols for HAIC have yet to be standardized. HAIC的技术和方案尚未标准化。 The efficacy and safety of HAIC depend substantially on the quality of vascular redistribution. HAIC的有效性...

Two different percutaneous arterial access approaches have been used for HAIC: the first approach entails the use of implantable port-catheter systems, and the second approach involves repeated hepatic artery catheterization. 两种不同的经...

A standard chemotherapy regimen for HAIC has yet to be established, increasing the challenge of interpreting trial results. HAIC的标准化疗方案尚未建立，这增加了解释试验结果的挑战。 Cisplatin and 5-FU were the most commonly used chemotherap...

Studies on HAIC have included populations with various degrees of intrahepatic tumor burden, including the possible presence of PVT/EHS. 对HAIC的研究包括了不同程度肝内肿瘤负荷的人群，包括可能存在PVT/EHS。 Studies on patients with PVT who r...

Immune checkpoint inhibitorbased combinations have changed the treatment paradigm for advanced HCC [59,60] and are likely to remain the cornerstone of systemic treatment in the next few years. 基于免疫检查点抑制剂的联合治疗已经改变了晚期HC...

HAIC combined with radiation therapy (RT) has also been extensively investigated, particularly in subgroups of patients with PVT. HAIC联合放疗(RT)也已被广泛研究，特别是在PVT患者的亚组中。 Han et al. [ 51 ] conducted a small-scale single-ar...

HAIC has been combined with sorafenib to leverage the synergistic effects of the combination. HAIC已与索拉非尼联合使用，以利用该联合使用的协同效应。 A randomized Phase 2 trial was conducted to compare HAIC plus sorafenib with sorafenib alo...