结直肠癌肝转移d-TACE的结果
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study | design | pts. | strategy | RR (%) | mOS mo | PFS mo |
Martin 2009 | retrosp. | 55 | salvage |
41 mRECIST 6 RECIST |
11 | 8 |
Huppert 2013 | prosp. | 29 | salvage |
72 mRECIST 0 RECIST |
8 | 5 |
Akinwande 2016 | prosp. | 15 | various |
73 mRECIST 33 RECIST |
13 | 8 |
RECIST is superior to mRECIST to stratify survival benefit according to response (evaluation of 228 mCRC pts treated with DE-TACE (91%) and Rembx 9%) Akinwande et al. 2016; J Surg Oncol 113:443-8
评估用228个结直肠癌肝转移的d-TACE患者(91%)和根据反应(用DE-TACE(91%)和Rembx方法(9%),RECIST优于mRECIST对生存效益进行分层)Akinwande et al. 2016; J Surg Oncol 113:443-8
RECIST vs. mRECIST in DE-TACE
Peter Hupper t • Thorsten Wenzel • Huber tus Wietholtz Transcatheter Arter ial Chemoembolization (TACE) of Color ectal Cancer Liver M etastases by Ir inotecan-Eluting Microspheres in a Salvage Patient Population. Cardiovasc Intervent Radiol 2014;37:154-64
生存率:整体生存率 vs 无病生存率 vs 肝无病生存率
(Survival: OS vs. PFS vs. hepatic PFS)
study | design | pts. | strategy | mOS mo | PFS mo |
Martin 2009 | retrosp. | 55 | salvage | 11 | 8 |
Fiorentini 2012 | pRCT | DEBIRI 36 | SL | 22 | 7 |
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FOLFIRI 38 |
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15 (p=.03) | 4 (p=.006) |
Narayanan 2013 | retrosp. | 28 | salvage | 13.3 | 4 |
Huppert 2013 | prosp. | 29 | salvage | 8 | 5 |
Iezzi 2015 | retrosp. | 20 | salvage | 7.3 | 4.0 |
Martin 2015 | prosp. | 30 FOLFOX | various | n.a. | 7.6 |
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30 FOLFOX |
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15.3 |
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+ DEBIRI |
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Akinwande 2016 | prosp. | 15 | various | 13 | 8 |
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cTACE |
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8-14 | 3-8 |