为什么选择载药微球 DEB治疗转移性肝癌的适应症D-TACE结果 并发症
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结直肠癌肝转移:d-TACE结果

时间:2020-12-15 23:49来源:未知 作者:Mr.Editor
结直肠癌肝转移d-TACE的结果 Outcome Parameters in DE-TACE 局部反应:RECIST vs mRECIST(EASL) study design pts. strategy RR(%) mOSmo PFSmo Martin2009 retrosp. 55 salvage 41mRECIST 6RECIST 11 8 Huppert2013 prosp. 29 salvage 72mRECIST 0RECIST

结直肠癌肝转移d-TACE的结果
Outcome Parameters in DE-TACE


局部反应:RECIST vs mRECIST(EASL)


study design pts. strategy RR (%) mOS mo PFS mo
Martin 2009 retrosp. 55 salvage 41 mRECIST
6 RECIST
11 8
Huppert 2013 prosp. 29 salvage 72 mRECIST
0 RECIST
8 5
Akinwande 2016 prosp. 15 various 73 mRECIST
33 RECIST
13 8


RECIST is superior to mRECIST to stratify survival benefit according to response  (evaluation of 228 mCRC pts treated with DE-TACE (91%) and Rembx 9%) Akinwande et al. 2016; J Surg Oncol 113:443-8

评估用228个结直肠癌肝转移的d-TACE患者(91%)和根据反应(用DE-TACE(91%)和Rembx方法(9%),RECIST优于mRECIST对生存效益进行分层)Akinwande et al. 2016; J Surg Oncol 113:443-8



RECIST vs. mRECIST in DE-TACE

 
Peter Hupper t • Thorsten Wenzel • Huber tus Wietholtz Transcatheter Arter ial Chemoembolization (TACE) of Color ectal  Cancer Liver M etastases by Ir inotecan-Eluting Microspheres in a Salvage Patient Population. Cardiovasc Intervent Radiol 2014;37:154-64
 
 
 

生存率:整体生存率 vs 无病生存率 vs 肝无病生存率
(Survival: OS vs. PFS vs. hepatic PFS)


study design pts. strategy mOS mo PFS mo
Martin 2009 retrosp. 55 salvage 11 8
Fiorentini 2012 pRCT DEBIRI 36 SL 22 7

 

 
FOLFIRI 38
 
15 (p=.03) 4 (p=.006)
Narayanan 2013 retrosp. 28 salvage 13.3 4
Huppert 2013 prosp. 29 salvage 8 5
Iezzi 2015 retrosp. 20 salvage 7.3 4.0
Martin 2015 prosp. 30 FOLFOX various n.a. 7.6

 

 
30 FOLFOX
 

 
15.3

 

 
+ DEBIRI
 

 

 
Akinwande 2016 prosp. 15 various 13 8

 

 

 

 

 

 
cTACE
 

 

 
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