药物洗脱微球PRECISION V 随机对照研究(2)

DC Bead showed significant advantage in patients with negative prognostic factors for objective response (p=0.038) and disease control (p=0.026)

TACE with DC Bead vs conventional TACE: median doxorubicin dose per procedure

结论：

DC Bead brings level or consistency and repeatability not available with conventional TACE 【1】
DC Bead guarantees increased and prolonged drug delivery to the tumor with minimal systemic exposure【1】
PRECISION V shows that DC Bead is safer that conventional TACE, in particular in relation to a highly significant reduction in liver toxicity and doxorubicin related toxicity
In PRECISION V, DC Bead - unlike conventional TACE - enabled consistent administration of high-dose doxorubicin treatment
In the short term of study duration (6 months), the resulting significant improvement in response was captured by “stress-test” analyses restricted to more vulnerable or advanced patients

D-TACE与C-TACE有相同的效果和安全性，而D-TACE术后腹部疼痛较少【Golfieri 2014】

dTACEvs cTACE 在整体生存率（OS）p=0.4，，无进展生存期（PFS）p=0.45；和移植生存率（transplantation fs）p=0.9 上也没有不同


未经调整的无进展生存期	使用倾向评分调整的无进展生存期。

杨宁介入医学网