术前准备 适应症与禁忌症 子宫肌瘤栓塞技术 并发症子宫肌腺症栓塞结果 争论
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时间:2023-03-28 22:54来源:www.ynjr.net 作者:杨宁介入医学网
高达 25% 的患者通常>40 岁; 2/3 有症状 使用 TVS(经阴道超声) 进行诊断,手术/介入栓塞前应MR检查 - 子宫腺肌病亚型和浸润深度对结局有影响 治疗将取决于表现:症状缓解(>40 岁)与不孕症(30 岁左右) 口服前列腺药和左炔诺孕酮释放宫内节育器药物治


高达 25% 的患者通常>40 岁; 2/3 有症状
 
使用 TVS(经阴道超声) 进行诊断,手术/介入栓塞前应MR检查 - 子宫腺肌病亚型和浸润深度对结局有影响
 
治疗将取决于表现:症状缓解(>40 岁)与不孕症(30 岁左右)
 
口服前列腺药和左炔诺孕酮释放宫内节育器药物治疗是一线治疗
 
子宫切除术是不希望保留子宫/生育能力对药物治疗无反应的女性的侵入性治疗金标准
 



子宫腺肌症病变切除Adenomyomectomy/细胞减灭术 cytoreductive surgery /高能聚焦超声 HIFU
  • 显示有效的症状缓解 have shown efficacy for symptomatic relief
  • 令人鼓舞的怀孕结果 encouraging pregnancy outcomes
  • 有限的资料,需要熟练的技术 limited data ; requires high-skill
  • 大多数有严重症状的病人年龄>40岁,并且已经有了孩子-一般不做  most severely symptomatic patients >40 years and already have children – not generally performed
 
UAE已被证明可安全有效地缓解症状,但缺乏关于妊娠结局的文献: UAE has shown to be safe and affective for symptom relief but literature lacking on  pregnancy outcomes: success 80-90%
  • 考虑行子宫切除术但希望保留子宫或避免手术的患者 patients considered for hysterectomy but wishing to preserve uterus or avoid surgery
  • 对患者未来生育计划的影响尚不明确 no clear role on patients with future fertility plans
 
子宫动脉栓塞被调整为非肿瘤栓塞:比起子宫肌瘤栓塞需要更小的栓塞剂和更进一步的栓塞终点 UAE technique adjusted for non-tumoral embolization: smaller-sized embolics and more  aggressive embolization end-point than UFE
 
患者应该知情一旦治疗失败,7年间面临20%的子宫切除率,比子宫肌瘤栓塞几率大。Patients should be informed on clinical failure rate leading to histerectomy – 20% up to 7  years > than for fibroids


however, UAE for adenmyosis is considered controversial by some authors since recurrence of symptoms has been observed in small case series.
(Goodwin JVIR 1999; Smith JVIR 1999)

nevertheless, some centers have continued UAE, due to  persistent requests from patients and gyne’s.(Kitamura AJR 2006; Kim AJR 2007)
 
 
未来RCT研究,等待QUEST临床实验结果   Future RCTs – QUESTA trial
 
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