杨宁介入医学网

HAIC combined with radiation therapy (RT) has also been extensively investigated, particularly in subgroups of patients with PVT.

HAIC联合放疗(RT)也已被广泛研究，特别是在PVT患者的亚组中。
 

Han et al. [51] conducted a small-scale single-arm pilot study of three-dimensional conformal RT followed by HAIC for HCC; they observed an ORR of 45% with manageable adverse events.

Han等人。[51]进行了一项小规模单臂试点研究的三维适形放疗和HAIC治疗HCC；他们观察到ORR为45%，不良事件可控。

Concurrent, continuous infusion hepatic arterial 5-fluororacil (5-FU) was delivered during the first and fifth weeks of radiotherapy.在放射治疗的第1周和第五周，同时持续输注肝动脉5-氟氧嘧啶（5-FU）。  After CCRT hepatic arterial infusion chemotherapy (HAIC) with 5-FU and cisplatin (DDP) was performed every 4 weeks.CCRT术后，每4周进行一次使用5-FU和顺铂(DDP)的肝动脉输注化疗(HAIC)。  CCRT, concurrent chemoradiation therapy, IA, intra-arterial; Gy, gray; Dx, diagnosis; CT, chemotherapy; R15, indocyanine green R15; AFP, α-fetoprotein. CCRT、同步放化疗、IA、动脉内、Gy、格瑞、Dx、诊断、CT、化疗、R15、R15、AFP、α-胎蛋白。

 

Investigators from Hiroshima University, Japan, have published a series of retrospective studies comparing HAIC plus RT with HAIC alone, focusing on patients with PVT.

来自日本广岛大学的研究人员发表了一系列回顾性研究，比较了HAIC+RT和单独使用HAIC，重点关注PVT患者。
 

Their results revealed impressive ORRs in the HAIC-RT combination arm, but no significant survival benefits were observed

他们的结果显示，HAIC-RT联合组的ORR令人印象深刻，但没有观察到显著的生存获益。 [52,53].
 

Furthermore, Kodama et al.[54] retrospectively reviewed the effects of HAIC plus RT compared with treatment with sorafenib in patients with major PVT (Vp3/4) by using case–control matching analysis.

此外，Kodama等。[54]采用病例-对照匹配分析，回顾性分析了HAIC+RT与索拉非尼治疗对重度PVT(Vp3/4)患者的疗效。

 

The HAIC-RT combination group demonstrated more favorable clinical outcomes, including OS (median survival, 9.9 vs. 5.3 months, p = 0.002) and progression-free survival (median survival, 3.9 vs. 2.1 mouths  p = 0.048).

HAIC-RT联合治疗组显示出更有利的临床结果，包括OS(中位生存期，9.9 vs.5.3个月，p=0.002）和无进展生存期(中位生存期，3.9 vs.2.1个月，p=0.048).

 

The findings of these studies indicate that HAIC plus RT may yield favorable ORRs and survival benefits; nevertheless, evidence from prospective randomized controlled studies is still unavailable.

这些研究的结果表明，HAIC+RT可能产生良好的ORR和生存益处；然而，来自前瞻性随机对照研究的证据仍不可获得。