药物洗脱微球栓塞治疗肝转移癌的适应症
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study | design | pts. | strategy | oRR (%) | mOS mo | PFS mo |
Fiorentini 2007 | retrosp. | 20 | salvage | 80 (?) | n.r. | n.r. |
Martin 2009 | retrosp. | 55 | salvage |
41 mRECIST 6 RECIST |
11 | 8 |
Narayanan 2013 | retrosp. | 28 | salvage | 45 mRECIST | 13.3 | 4 |
Huppert 2013 | prosp. | 29 | salvage |
72 mRECIST 0 RECIST |
8 | 5 |
Iezzi 2015 | retrosp. | 20 | salvage | 10 RECIST | 7.3 | 4.0 |
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cTACE |
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8-14 | 3-8 |
DE-TACE in Salvage Patients
Outcome in Salvage Patients |
降期切除 (Downstaging to Resection)
study | design | pts. | oRR (%) |
mOS mo |
PFS mo |
Downstaging to resection |
Martin 2009 | retrosp. | 55 |
41 mRECIST 6 RECIST |
11 | 8 | 6/55 (10%) |
Akinwande 2016 | prosp. | 15 |
73 mRECIST 33 RECIST |
13 | 8 | 2/15 (13%) |
Consolidation in Liver dominant disease
study | design | pts. | strategy | oRR (%) | mOS mo | PFS mo |
Martin 2015 | prosp. | 30 FOLFOX | various | 60 mRECIST | n.a. | 7.6 |
30 FOLFOX + DEBIRI |
76 |
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15.3 |