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肿瘤介入中的三维可视化影像

时间:2016-01-31 21:21来源:未知 作者:Mr.Editor
旋转平板透视最近的进展(或锥束CT,cone-beam CT)结合了类CT多平面成像透视的实时成像的优点【5254】。这些图像的表现在肿瘤检测方面优于标准血管造影【55】。软件可用于三维血管造影数据重建,在各个方向上显示肿瘤滋养血管并因此提供经导管治疗的引导【5
 

        旋转平板透视的进展(或锥束CT,cone-beam CT),有类CT多平面成像和实时透视的成像的优点【52–54】。这些图像的表现在发现肿瘤方面优于标准血管造影【55】。另外其软件设计功能可用于三维血管造影数据重建,在各个方向上显示肿瘤滋养血管并因此提供经导管治疗的引导【56】。改变了日常临床介入的工作实践

Hybrid Operating Room (Artis ZEEGO):肿瘤和其它部位介入治疗专门设计



除了提供类CT成像,医生还获得了典型透视下介入操作的空间。已经有X射线透视机功能的血管造影机,在肿瘤介入成像设备中具有更强大的角色【57】。

3D acquisition is routenely used
血管3D成像 类CT成像 医生还获得了典型透视下介入操作的空间



介入手术室内的许多操作需要在全麻下进行

Changes in clinical practice

Devellopement hybrid procedure with GI surgeon
and endoscopist (Multidisciplinary team)
Modify Artis Zego table for coelioscopic surgery



62-year-old woman with hepatocellular carcinoma in right lobe of liver.
Multiplanar reconstruction image with graphic inputs from C-arm cone beam CT system (Artis Zee BA Twin, Siemens Healthcare) shows progression view. We initially define target site (red circle) and skin-entry point (yellow cross) on image. Needle path (green line) is then automatically projected
Software automatically computes necessary C-arm angulation for bull's eye view. The C-arm is brought to this position under physician's input. Radiologist manipulates ablation needle shaft (white arrow) such that both needle tip and hub are superimposed on center of circle representing target site, and needle is inserted straight.
Real-time fluoroscopic images with C-arm are immediately obtained in progression view, and needle is advanced along planned needle path (dotted line) to target site (white circle).
Panel shows contrast-enhanced C-arm cone beam CT image obtained just after radiofrequency ablation in progression view to screen for residual vascularity.
 

        虽然致密的结构,如骨和血管内造影剂使这些设备系统是足以实现可视化成像,在软组织分辨率和显示范围(FOV)挑战依然存。随着这一相对较新的技术的提高,许多CT引导下介入治疗可能会减少。

         虽然CT、MRI和超声影像仍然主要在二维模式中使用,正在进行的努力是更多地应用三维影像【58】。例如,对于一个肿瘤成功地进行消融手术包括整个肿瘤的治疗,而且没有邻近结构的有害影响【59】。因此,术中肿瘤和其周围3D显示很可能改善消融的结果。早期的研究提示3D影像有助于消融电极的放置【60】。用3D影像显示的限制之一是需要时间重建影像并显示给施术者。所以快速3D影像重建的能力将有助于介入治疗【61】。


( a) Transverse CT scan shows radiofrequency ablation applicator (arrow) (Cool Tip; Valley Labs, Boulder, Colo) that appears to be in the center of 1.5-cm non–small cell lung cancer; however, (b) sagittal reconstructed CT scan shows how in reality the applicator (arrow) may be centered in the x-y dimension but not in the z dimension. The applicator is in the superior portion of the tumor, not in its center. (c, d) Different patient with three radiofrequency ablation applicators (Cool Tip) placed in a 3.5-cm non–small cell lung cancer (arrows).
(c) Sagittal and (d) transverse oblique reconstructions help determine appropriate 3D spacing of the applicators.


Segmentation of structures from multiple 2D MR images to generate 3D models for volume calculations and 3D assessment of liver tumor ablations.
Postprocedural enhanced axial MR image (T1-weighted fast multiplanar spoiled gradient-echo; TR/TE, 310/1.6; flip angle, 75°; section thickness, 5 mm; field of view, 40 cm) obtained at 48 hr shows teardrop-shaped nonenhancing region of cryonecrosis (arrow). Tumor is seen as hyperintense structure (arrowhead) relative to ablated tissue.
 Three-dimensional models of structures of interest are shown including tumor (green), liver (brown), and cryonecrosis (blue).
 
 
Structures outside liver (gallbladder in yellow, colon in purple, and kidney in red) add perspective and provide guidance in planning interventional access.


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