Highest intratumoral concentrations at 3 days (40.632-50.052nM/g，7 days drop at 23.1372nM/g)
Photomicrographs (all hematoxylin and eosin [H&E] stain)
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Multiple eosinophilic QuadraSpheres occluding a vessel (original magnification, ×50). QuadraSpheres were deformed and conformed to the morphology of the vessel lumen and adjacent |
In tumor tissue, most of the QuadraSpheres were eosinophilic with occasional clefts; however, a few of the QuadraSpheres were basophilic |
QuadraSpheres were deformed and conformed to the vessel lumen and adjacent particles, whereas Embospheres retained their spherical shape |
50-100μm Quadrasphere +4mg doxorubicin
Hepatic Arterial Infusion (HAI) with doxorubicin
TACE with doxorubicin/ lipiodol and 100-300μm Embospheres
兔VX2癌模型分为肝动脉灌注组（HAI）、碘油TACE组（TACE）和载药微球组（QuadraSphere）
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治疗前和治疗后10, 20, 40, 60, 120, 和 180分，所有三组血浆表阿霉素浓度在10分钟为高峰，回到接近正常基线为60分钟，持续24小时保持在低位。虽然QuadraSphere血浆浓度显著低于肝动脉灌注组(309.9 ng/ml versus 673.4 ng/mL; p = 0.0183)和TACE组，但没有显著性差异。 |
