| 名词和定义：Neoadjuvant chemotherapy by hepatic infusion for given to resectable liver metastases to facilitate surgery 经导管新辅助化疗（neoadjuvant or primary chemotherapy by hepatic arterial infusion）是指在肝转移病变局部实施手术之前，先行经肝动脉局部化疗。 研究一：Pre-Op FOLFOX4 in Pts With Resectable Liver Mets EORTC 40983【1】  结果1 入组病人PFS/年 （HR = 0.77; CI 0.60–1.00, P = .041）【2】
结果2：Overall survival in randomized patients
We conclude that perioperative FOLFOX4 chemotherapy reduced the risk of events of progression-free survival by a quarter and was compatible with major surgery. In all randomised patients the study showed a trend favouring administration of chemotherapy. In all eligible and in all resected patients, the benefit of administering chemotherapy was significant. 研究三：术前化疗的肝脏毒性【3】 1. 5FU：肝脏脂肪变（Hepatic steatosis） 2. 伊立替康（Irinotecan）：肥胖者非酒精性脂肪性肝炎（Non-alcoholic steatohepatitis）可以影响肝脏储备和增加并发症。 3. 奥沙利铂（Oxaliplatin）肝窦阻塞综合征（hepatic sinusoidal obstruction syndrome）-蓝肝（Blue liver）
Enlarged Spleen After Systemic Oxaliplatin/FU/LV Chemotherapy
1. Gruenberger. ASCO Abstracts 3500, 2006. 2. Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, Bechstein WO, Primrose JN, Walpole ET, Finch-Jones M, Jaeck D, Mirza D, Parks RW, Collette L, Praet M, Bethe U, Van Cutsem E, Scheithauer W, Gruenberger T; EORTC Gastro-Intestinal Tract Cancer Group; Cancer Research UK; Arbeitsgruppe Lebermetastasen und-tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie (ALM-CAO); Australasian Gastro-Intestinal Trials Group (AGITG); Fédération Francophone de Cancérologie Digestive (FFCD). Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008 Mar 22;371(9617):1007-16. 3. Zorzi M, Barca A, Falcini F, Grazzini G, Pizzuti R, Ravaioli A, Sassoli de Bianchi P, Senore C, Sigillito A, Vettorazzi M, Visioli C. Screening for colorectal cancer in Italy: 2005 survey. Epidemiol Prev. 2007 Mar-Jun;31(2-3 Suppl 2):49-60. |
