溶栓治疗主要限制在急性下肢缺血并且存活（viable）的肢体。部分基于TOPAS和STILE试验的结果，2005 年 American College of Cardiology/American Heart Association （ACC/AHA) 与血管内科、血管外科和介入放射学相关协会达成共识：一般同意经导管溶栓治疗（catheter-based thrombolytic therapy）是有效和获益的[1]，适合于急性肢体缺血＜14天的患者[1]。对于急性肢体缺血大于14天的病人如何治疗的证据还没有成熟。 该共识也认为有足够的证据表明周围动脉阻塞导致的急性肢体缺血机械性血栓切除术的重要性。 1. Hirsch AT, Haskal ZJ, Hertzer NR, et al. ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. Circulation 2006; 113:e463.
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