结论:
1. 原发性顽固性高血压的基于导管的去肾交感神经支配术多中心随机试验显示可以持续和显著降低顽固性高血压患者血压
2. 血压下降的程度能够预期高血压相关疾病进展的影响
3. 这项技术没有操作相关的肾功能和肾动脉严重的并发症
4. 基于原发性高血压神经病生理学的这项技术革新证实了高血压病人维持血压肾神经的重要相关性
5. 去肾交感神经支配术作为辅助治疗对原发性高血压病人是获益的
RSD的疗效是否具有广泛的适用性,尚需要进一步验证。 Krum等[17]指出, RSD理论上不仅可用于难治性高血压人群,也可用于其他交感神经过度激活的疾病,如该技术的可以应用到慢性肾病、左心室肥厚,包括收缩期和舒张期慢性心力衰竭;能否向众多早期轻度高血压人群推广该治疗尚需具有更长期随访的大规模的研究来进一步评估这种新的介入方式,但目前的结论是令人鼓舞的。
去肾交感神经支配术的其它临床研究
1. 糖代谢的研究
2. 睡眠呼吸暂停综合征的研究
3. 多囊卵巢综合征的研究
4. 心律失常研究
5. 肥胖研究
6. 慢性肾病的研究
7. 其它研究
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