胰腺癌在北美最常见的肿瘤中，排在第10位[1]，每年诊断38，000病人，数目差不多的病人死于这种疾病[8,9]，占癌症死亡原因的第4位。由于其侵入性的生物特性，出现症状而诊断胰腺癌时，85%~90%的病人已经因为局部晚期或远处转移而失去治愈性手术机会。因此，整体生存率不超过5%[2,3]。甚至病人进行了治愈性切除手术，实际5年生存率不超过10%~20%[4~7]，预后非常差。 1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43–66. 2. Carpelan-Holmstrom M, Nordling S, Pukkala E, Sankila R, Luttges J, Kloppel G, et al. Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry. Gut 2005;54:385–7. 3. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, et al. Cancer statistics, 2005. CA Cancer J Clin 2005;55:10–30. 4. Cleary SP, Gryfe R, Guindi M, Greig P, Smith L, Mackenzie R, et al. Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors. J Am Coll Surg 2004;198: 722–31. 5. Yeo CJ, Sohn TA, Cameron JL, Hruban RH, Lillemoe KD, Pitt HA. Periampullary adenocarcinoma: analysis of 5-year survivors. Ann Surg 1998;227:821–31. 6. Sperti C, Pasquali C, Piccoli A, Pedrazzoli S. Survival after resection for ductal adenocarcinoma of the pancreas. Br J Surg 1996;83: 625–31. 7. Ozaki H, Hiraoka T, Mizumoto R, Matsuno S, Matsumoto Y, Nakayama T, et al. The prognostic signifi cance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection. Surg Today 1999;29:16–22. 8. Jemal, A. et al. Cancer statistics. CA Cancer J. Clin. 58, 71—96 (2008).
9. Canadian Cancer Society/National Cancer Institute of Canada: Canadian Cancer Statistics 2008, Toronto, Canada, 2008. April 2008, ISSN 0835—2976. |